Molecular Mechanisms of Patupilone Resistance

Molecular mechanisms involved in multidrug resistance in breast cancer therapy

Breast cancer is the most prevalent cancer in women. Chemotherapy is the main strategy in the treatment of this disease especially in the advanced form of the disease. Despite the recent progress in the development of new chemotherapy, the effectiveness of these drugs has dramatically reduced due to multidrug resistance. The phenotype of multidrug resistance (MDR) can occur through different me...

Molecular mechanisms of drug resistance.

Molecular Mechanisms of Antimicrobial Resistance

In the last 50 years bacteria have demonstrated a remarkable ability to develop and share resistance to every antibiotic that has been developed, often by quite unexpected mechanisms and much more readily than was originally predicted (Spratt, 1994). Antibiotic resistant bacteria can live and multiply in the presence of therapeutic levels of antibiotics. They can be resistant in their natural s...

Aspirin Resistance: Molecular Mechanisms & Techniques

Aspirin became a cornerstone in the treatment of coronary artery disease and widely used in the secondary prevention of vascular events. Aspirin resistance remains a poorly defined term though clinical definition is failure of the drug to prevent an atherothrombotic event despite the regular intake of appropriate doses is a relatively common problem. Various laboratory parameters assessing its ...

Molecular Mechanisms of Recurrent Pregnancy Loss

Introduction: Pregnancy and health is the process in which the egg is fertilized and being able to survive. When pregnancy occurs under some conditions and the fetus is being at risk, it will lead to abortion that occurs involuntarily and spontaneously. Abortions that occur more than two or three times are called recurrent pregnancy loss (RPL). Various etiological factors involved in RPL, inclu...